The Infinite Possibilities of Enzyme Engineering


Protein engineering is a powerful tool in synthetic biology that can create proteins with tremendous potential for therapeutic and industrial use. The field has recently taken giant leaps forward from its origins, and some of its pioneers predict that the next five to ten years hold exponentially more promise. Early protein engineering was what David Baker, Ph.D., director of the Institute for Protein Design at the University of Washington, called “Neanderthal protein design.” “You’d look around in nature for something where you could make a couple of amino acid substitutions.

 It’s like when early humans needed a tool, they’d sharpen a stick or bone for their purposes. But that’s not really protein engineering. Rather than strapping a human onto a bird, you figure out the principles of flight and design something like an airplane. That’s true protein engineering: building proteins completely from scratch, engineered to do what you want them to do.”

Philip Romero, Ph.D., an assistant professor of biochemistry at the University of Wisconsin, uses computational methods to investigate the relationships between protein sequence, structure, and function—identifying sequences tied to useful properties that he can then engineer into new proteins with the functions he wants. “We generate sequence function data sets, see how the sequence maps to some property we want to optimize, and use ideas from statistics and machine learning to understand how interactions between residues contribute to those properties.”

To kick-start the process, his lab is combining artificial intelligence with robotic automation. “In the past, a grad student or post-doc would make the mutations in a protein, evaluate the effects, and come up with a hypothesis for how the protein is working. Then they would make more mutations, repeat the process five or ten times, and slowly get something improved. We think we can fully automate the entire process.”

Our esteemed journal EEG is looking forward for the upcoming issue (Volume8: Issue2) having journal impact factor of 1* and nearly 83 articles are cited in Google scholar site. We are glad for the upcoming year issue release as all the authors are invited to submit their recent scientific work through manuscripts in the mode of Research/Case Reports/Case Studies/Reviews/Short Review/ Short Communications/Commentaries/Short Commentaries/Letters to Editor/ Image articles etc., from different regions around the world.

Our Journal welcomes submissions of manuscripts on the topics covering Bioprocess, Enzyme Expression, Enzyme Kinetics, Protein InteractionProtein Purification, Protein  Engineering, Enzyme, Metabolic Engineering, etc. In the quality perspective, the journal is determined to maintain an exceptionally high standard in both facts and ethics. Accuracy and authenticity in the scientific reports of present journal are conserved above all nominal needs of the time.

A standard editorial manager system is utilized for manuscript submission, review, editorial processing and tracking which can be securely accessed by the authors, reviewers and editors for monitoring and tracking the article processing. Manuscripts can be uploaded online at Editorial Tracking System or as an email attachment to

Best Regards
Jessie Franklin,
Editorial Manager,
Editorial Team,
Enzyme Engineering: Open-Access
Contact: +32-2-808-7017