The Effect of Selenium on Hashimoto’s Thyroiditis: Systemic Review and MetaAnalysis


The Journal of Clinical Toxicology (JCT) is Scholarly Open Access journal that deals with the study of xenobiotics and alsostudy toxic effects of agents (drugs) whose purpose is to ameliorate or prevent a disease. The journal addresses both scientific research and clinical advances in clinical toxicology. This free clinical journal provides an open access platform for researcher’s work in clinical toxicology in hospitals, academia, government or industrial sectors.

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JCT has recently released article entitled “The Effect of Selenium on Hashimoto’s Thyroiditis: Systemic Review and MetaAnalysis” whose abstract is as follows:

Background:  Selenium  forms  a  significant  component  of  seleno-proteins  in  the  body.  Seleno-methionine  isintegrated into proteins instead of methionine and acts as a storage pool. In proteins, the active form of Selenium this review we aim to prevail the results of selenium effect on thyroid status in recent clinical trials.The systemic review aims to find out the correlation between supplementation of Selenium and anti-TPO antibodiesand T4 levels in Hashimoto’s Thyroiditis. Selenium supplementation decreases the level of anti-TPO antibodies. Thesupplementation of Selenium increases the level of T4 levels.

Methods: The mean and standard deviation (SD) of all 8 studies was were calculated. One of the researches had allthe information in figures, and only the levels of anti-TPO antibodies and FT4 were obtained. Heterogenicity wasestimated using I2.

Results:  The  p-value  calculated  for  Anti-TPO  by  SPSS  of  the  eight  groups  had  a  p-value  of  0.142.  The  p-valuecalculated for T4 levels by SPSS of the five groups had a p-value of 0.239. The heterogenicity test was zero after the I2test. The studies that were included in the systematic review were assessed by Prisma diagram and selected among thearticles resulted from search keywords selenium and anti TPO and hashimotho thyroiditis on different data sources.All the participants were evaluated by sex, ages, duration of the study and the levels of anti TPO AB and thyroxin (t4)and then using SPSS software to deploy metanalysis in the systematic review.

Conclusion: In 6 of 8 studies it was a relation of selenium and thyroid status, whereas 2 studies were not. As we ranmeta analysis on the data we realized that there is not significant desired effect from selenium on thyroid antibodiesagainst previous metanalysis done by other researchers.

Keywords: Selenium; Autoimmune thyroiditis; Anti-TPO antibodies

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