Immuno-Oncological Mechanism of Cancer


Immuno-Oncological Mechanism of Cancer

Many chronic complex diseases such as cancer, diabetes, and asthma are being redefined as heterogeneous and the deregulation of the immune system is at the heart of many of these diseases. Due to the complexity of the immune system, it has become evident that a multidisciplinary approach is essential for gaining a thorough understanding of the mechanisms involved in modulating the immune system in various diseases. Systems immunology brings together methodologies and tools from the fields of mathematics, engineering, physics, and computer science to gain a better understanding of the control, regulation and feedback loops within the immune system and how these processes are implicated in disease, from early to advanced stages.

In the context of cancer, systems immunology approaches are now enabling us to gain insight into the dynamics between the immune system and the tumor microenvironment and how differential regulation of immune responses contribute to the pathogenesis of cancer and patient outcome. These approaches are highly promising for accelerating the identification of more effective immunotherapeutic molecules, such as immuno-modulatory antibodies, that can be used to treat and potentially eliminate cancer. In addition, the use of systems immunology can provide beneficial insights into how targeted cancer therapies such as photodynamic (PDT) and sonodynamic (SDT) therapy, as well as photochemical internalization (PCI) affect anti-tumor immune responses and the composition of the tumor microenvironment.

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Media Contact:
Stella M
Journal Manager
Immunome Research