HLA Allele Distribution in Romanian People: Clinical Significance and Utility Related to Population Genetic Background


HLA Allele Distribution in Romanian People: Clinical Significance and Utility Related to Population Genetic Background

He HLA complex is defined by the genes of the Major Histocompatibility Complex (MHC). Нese loci play a key role in the immune system response and are among the most polymorphic in humans, comprising more than 20 genes, Here loci have been studied extensively for at least four reasons: (i) for donor-recipient matching in organ and stem cell transplantation success, (ii) due to associations between polymorphisms and response to infectious diseases or susceptibility to autoimmune diseases, (iii) due to associations between particular HLA polymorphisms and increased risk for adverse drug reactions, (iv) the HLA region is also commonly analyzed in anthropology studies

He study represents our first approach of HLA genotype characterization. In the future, we aim to extend our analysis of Romanian population on C, DQB1 and DPB1 loci at high resolution level. Taking into account the increasing number of bone marrow transplants in our country and the initiation of the HLA-haploidentical bone marrow transplantation, we believe that it would be extremely beneficLal to analyze the HLA haplotypes frequencies and distribution.

Analysis of genetic differences between distinct Romanian population groups and European Caucasian population leads to the conclusion that Romanian people is of European origin. Massive population migration could increase the possibility of more polymorphic HLA allele distribution over all European regions. It would be very interesting to look at HLA allele polymorphisms in different regions of European countries in order to be able to design an HLA allele distribution map. НLs work is valuable in establishing HLA typing strategies within the Volunteer Bone Marrow Donors National Registries in Europe, sustaining the eوٴorts of findLnJ the best matched donor for the patients in need. Last but not least, HLA disease associations could be implemented in many diagnostic algorithms revealing specLfic genetic information for many conditions. Furthermore, other clinical applications of HLA allele’s assessment could be relevant for the genetic background of rare diseases and disease susceptibility.

Immunogenetics: Open access journal focuses on the genetic research areas of autoimmune disorders such as multiple sclerosis, rheumatoid arthritis, Crohn’s disease, diabetes mellitus type 1, systemic lupus erythematous, etc.

Articles on genetics of cell interaction with immune system, immune response to transplantation, immune based therapies for treatment of cancers, antigenic phylogeny of alleles, alloantigens are also welcome.

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