Acute myelogenous leukemia â€“ Symptoms, Diagnosis and Treatment
Acute myelogenous leukemia – Symptoms, Diagnosis and Treatment
Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. It is a bimonthly journal. Here we discuss about acute myelogenous leukemia – Symptoms, Diagnosis and Treatment.
Acute myelogenous leukemia (AML) is a cancer of the blood and bone marrow — the spongy tissue inside bones where blood cells are made.
The word "acute" in acute myelogenous leukemia denotes the disease's rapid progression. It's called myelogenous (my-uh-LOHJ-uh-nus) leukemia because it affects a group of white blood cells called the myeloid cells, which normally develop into the various types of mature blood cells, such as red blood cells, white blood cells and platelets.
Acute myelogenous leukemia is also known as acute myeloid leukemia, acute myeloblastic leukemia, acute granulocytic leukemia and acute nonlymphocytic leukemia.
General signs and symptoms of the early stages of acute myelogenous leukemia may mimic those of the flu or other common diseases. Signs and symptoms may vary based on the type of blood cell affected.
Signs and symptoms of acute myelogenous leukemia include:
- Fever, Bone pain, Lethargy and fatigue, Shortness of breath, Pale skin, Frequent infections, Easy bruising, Unusual bleeding, such as frequent nosebleeds and bleeding from the gums.
- Blood tests.
- Bone marrow test
- Lumbar puncture (spinal tap).
- Genomic testing
Treatment of acute myelogenous leukemia depends on several factors, including the subtype of the disease, your age, your overall health and your preferences.
In general, treatment falls into two phases:
- Remission induction therapy.
- Consolidation therapy.
Therapies used in these phases include:
- Targeted therapy.
- Other drug therapy.
- Bone marrow transplant.
Prior to a bone marrow transplant, you receive very high doses of chemotherapy or radiation therapy to destroy your leukemia-producing bone marrow. Then you receive infusions of stem cells from a compatible donor (allogeneic transplant).
You can also receive your own stem cells (autologous transplant) if you were previously in remission and had your healthy stem cells removed and stored for a future transplant.
- Clinical trials. Some people with leukemia choose to enroll in clinical trials to try experimental treatments or new combinations of known therapies.
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